blaes fə mi
noun
disrespect or irreverence toward something considered sacred or inviolable, esp. God.
The notion that the earth is not the center of the solar system was at one time considered blasphemy.
They think it blasphemy to question the existence of God. The rogue priest was chastised for his blasphemy.
To suggest that the standard treatment for the disease might be doing more harm than good was blasphemy in the medical community.